The EU NanoSafety Cluster invites you to participate in its forthcoming webinar:
”Immune response from occupational exposure to CNTs and nanofibers”
Date: Tuesday, June 30, 2020
Time: 2:00 PM – 3:30 PM BST
Register for free here: https://tinyurl.com/nsc-webinar-registration
This highly informative event is organised under the aegis of CDC work on association of occupational exposure with ex vivo functional immune response in workers handling carbon nanotubes and nanofibers
About this Event
Speakers are from the Centers for Disease Control and Prevention (CDC)
-Matthew Dahm – CNT/F exposure assessment
-Aaron Erdely – Occupational exposure and immune effects
-Mary K. Schubauer-Berigan – Cross-sectional evaluation of CNT/F workers
The study objective was to evaluate the association between carbon nanotube and nanofiber (CNT/F) exposure and ex vivo responses of whole blood challenged with secondary stimulants in a cross-sectional study of 102 workers.
Multi-day exposure was measured by CNT/F structure count (SC) and elemental carbon (EC) air concentrations. Whole blood collected from each participant was incubated with and without two microbial stimulants (lipopolysaccharide/LPS and staphylococcal enterotoxin type B/SEB) using TruCulture technology to evaluate immune cell activity.
The stimulant:null response ratio for each individual protein was analyzed using multiple linear regression, followed by principal component (PC) analysis to determine whether patterns of protein response were related to CNT/F exposure.
CNT/F exposure metrics were significantly inversely associated with stimulant:null ratios of several individual biomarkers as well as PC1 and PC2, illustrating a reduced immune response. This approach may present a relatively sensitive method to evaluate human response to CNT/F or other occupational exposures.